Cytotoxic terpenoids from the fruits of Vitex trifolia L.
نویسندگان
چکیده
Two new labdane-type diterpenoids vitetrifolin H (1) and vitetrifolin I (2), and one new monoterpenoid vitexoid (3), were isolated from the fruits of Vitex trifolia L., together with seven known diterpenoids. Structures of all compounds were elucidated by extensive spectroscopic methods. All these compounds exhibited inhibition of Hela cell proliferation, with IC50 values in the range of 4-28 microM. In addition, vitetrifolin I (2) induced cell cycle G0/G1 phase arrest and apoptosis of Hela cells.
منابع مشابه
Labdane-type diterpenoids from the fruits of Vitex trifolia.
Seven new labdane-type diterpenoids, vitextrifolins A-G (1-7), along with eight previously reported analogues, were isolated from the fruits of Vitex trifolia. The structures of 1-7 were elucidated by spectroscopic data interpretation. The isolates were evaluated for their cytotoxicity against four human cancer cell lines (A549, HCT116, HL-60, and ZR-75-30), but all were inactive (IC(50) < 5 μg...
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ورودعنوان ژورنال:
- Planta medica
دوره 75 4 شماره
صفحات -
تاریخ انتشار 2009